Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1166
Protein Name
Aquaporin Z
Gene Name
aqpZ; BB2145
Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Length
236 amino acids
AlphaFoldDB
AF-Q7WKG2-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MQPLFKRCGAEFFGTFWLVLGGCGSAVLAAGVPQVGIGYAGVALAFGLTVLTMAYAVGHISGGHFNPAVTVGLAASGRFGWRDVPPYIVAQVVGAIVAAATLASIAQGVAGFDLVASKFAANGYGDHSPGKYSMQAALICEIVLSAGFVFVILGATDKRAPAGFAPIPIGLALTLIHLISIPVTNTSVNPARSTGPALFVGGWALEQLWLFWLAPIAGALVGALAYRLVGTPSAQR
PDB Structures
Ligand Binding
Binding Site
SITE 23: "Involved in tetramerization or stability of the tetramer"; SITE 46: "Selectivity filter"; SITE 177: "Selectivity filter"; SITE 186: "Selectivity filter"; SITE 192: "Selectivity filter"
Disease
Location
DOI ID
10.1038/ng1227
RefSeq
WP_003812617.1